Citation

Pitchot W, Scantamburlo G, Pinto E, Hansenne M, Reggers J, Ansseau M, Legros JJ. J. Psychiatr. Res. 2008; 42(8): 684-688.

Affiliation

Department of Psychiatry, Psychoneuroendocrinology Unit, University of Liège, CHU of Liège, B-4000 Liège, Belgium.

Copyright

(Copyright © 2008, Elsevier Publishing)

DOI

10.1016/j.jpsychires.2007.07.007

PMID

17720191

Abstract

The purpose of the present study was to assess if AVP-neurophysin is associated with hypercortisolemia and suicidal behaviour in depressed patients. The study included 28 patients subgrouped into suicide attempters (n=13) and nonattempters (n=15). We assessed basal AVP-neurophysins concentrations and post-dexamethasone (DST) cortisol levels. Concentrations of AVP-neurophysins did not differ between DST suppressors and nonsuppressors: 0.29+/-0.13 ng/ml vs 0.36+/-0.21 ng/ml, (F=1.1, df=1, 27, p=0.30). Suicide attempters did not differ from nonattempters for AVP-neurophysins levels. Our results fail to support a role of AVP in the early cortisol escape.

Language: en