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Journal Article

Citation

Lee BH, Lee SW, Yoon DK, Lee HJ, Yang JC, Shim SH, Kim DH, Ryu SH, Han C, Kim YK. Neuropsychobiology 2006; 53(3): 127-132.

Affiliation

Department of Psychiatry, College of Medicine, Korea University, Seoul, Korea.

Copyright

(Copyright © 2006, Karger Publishers)

DOI

10.1159/000092542

PMID

16601363

Abstract

OBJECTIVE: To evaluate any correlation between plasma levels of nitric oxide metabolites (NO(x)) and suicide attempt. METHOD: Plasma NO(x) levels were measured in 53 patients who had recently attempted suicide, 58 non-suicidal psychiatric patients, and 75 normal controls. The severity of suicidal behaviors was evaluated using Weisman and Worden's Risk-Rescue Rating Scale. RESULTS: Plasma NO(x) levels were significantly higher in suicidal patients than non-suicidal psychiatric patients or normal control subjects (F=11.029, d.f.=2, 183, p<0.001). Among the patients with a diagnosis of major depression, suicidal depressive patients had significantly higher plasma NO(x) levels than non-suicidal depressive patients (t=-3.090, d.f.=84, p=0.003). CONCLUSION: Our study suggests that increased NO production in plasma is associated with suicide attempt, especially in depressive patients.


Language: en

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