Citation

Ke L, Qi ZY, Ping Y, Ren CY. Brain Res. 2006; 1122(1): 24-26.

Affiliation

Department of Preventive Medicine, Shantou University Medical College, Xinling Road #22, Shantou 515031, and Shandong Health Hospital, P.R. China. kli@stu.edu.cn

Copyright

(Copyright © 2006, International Brain Research Organization, Publisher Elsevier Publishing)

DOI

10.1016/j.brainres.2006.09.007

PMID

17011525

Abstract

OBJECTIVE: The novel tryptophan hydroxylase isoform (TPH2), being the rate-limiting enzyme in the biosynthesis of serotonin, has many biological functions and plays an important role as candidate gene in several psychiatric disorders. Here, an A-G single nucleotide polymorphism (SNP) at the position 40237 relative to 5'-end of TPH2 gene was selected for the association with suicide behavior. METHODS: The study population consisted of 102 MD patients with suicide behavior as attempters and 123 MD patients without suicide behavior as non-attempters. The TPH2 SNP was determined by sequencing on an ABI 3700 automated DNA sequencer. RESULTS: The A allele was significantly less frequent in attempters than in non-attempters (p=0.0067). Individuals with the A/A genotype showed a significantly lower risk of suicide behavior than those with the A/G or G/G genotype (OR=0.35). CONCLUSIONS: Our findings suggest that the A-G polymorphism of TPH2 may confer susceptibility to suicide behavior in MD patients.

Language: en