Citation

Anselmi L, Benza G, Nurra V, Derchi G, Nicolino RP. G. Ital. Cardiol. (Piccin) 1987; 17(8): 715-717.

Vernacular Title

Su un caso di intossicazione acuta volontaria da flecainide a scopo suicida.

Affiliation

Servizio di Cardiologia e U.T.I.C., Ospedale Civile di Sanremo.

Copyright

(Copyright © 1987, Piccin Editore)

DOI

unavailable

PMID

3121427

Abstract

A case of acute poisoning caused by an overdose of flecainide (1.5 gr. per os), taken in order to commit suicide, is described here. With a plasmatic concentration of 5000 ng/ml the drug induced a soporose condition, shallow breathing with phases of apnea and intermittent muscular clonuses, a clinical picture of shock with a idioventricular rhythm at a rate of 40/min. and widening of the QRS (400 msec.). The infusion of orciprenaline and 5% glucose solution induced an increase in the ventricular frequency and the normalization of the circulatory condition. Twenty hours after ingestion sinus rhythm was restored. Highest therapeutic level of flecainide was reached 48 hours after ingestion. The stimulation threshold during the acute phase was 1.8 mA and came down 1.3 mA after wash-out. The outcome was favourable.

Language: it