Citation

Perrot D, Bui-Xuan B, Lang J, Bouffard Y, Delafosse B, Faucon G, Motin J. J. Toxicol. Clin. Toxicol. 1988; 26(5-6): 389-396.

Affiliation

Department of Intensive Care Medicine, Hôpital Edouard Herriot, Lyon.

Copyright

(Copyright © 1988, Marcel Dekker)

DOI

unavailable

PMID

3193492

Abstract

The case of a 58 year old woman who died after ingestion of 14.4 g of sotalol and 50 mg of triazolam is described. Despite medical treatment, intracardiac pacing and hemodialysis, cardiovascular failure persisted and became irreversible. High sotalol concentrations were observed in plasma (65 micrograms/ml) and in post mortem tissues samples. Tissue to plasma ratios ranged from 2.5 to 6. The high drug concentration found in heart tissue (104.4 micrograms/g) explains the difficulties experienced in the sotalol poisoning.

Language: en