Citation

Holemans S, De Paermentier F, Horton RW, Crompton MR, Katona CL, Maloteaux JM. Brain Res. 1993; 616(1-2): 138-143.

Affiliation

Laboratoire de Neurochimie Université Catholique de Louvain, Brussels, Belgium.

Copyright

(Copyright © 1993, International Brain Research Organization, Publisher Elsevier Publishing)

DOI

unavailable

PMID

8358605

Abstract

Glutamate receptors of the NMDA-subtype were quantitated by binding of 3H.dizocilpine maleate (MK-801) in nine brain regions from 22 suicide victims (20-60 yr), with a firm retrospective diagnosis of depression, who had not recently received antidepressant drugs, and 20 age- and sex-matched controls. 3H.MK-801-binding did not differ between suicides and controls in any region studied. Suicides who died violently did not differ from non-violent suicides and controls. A significative negative correlation was found between age and NMDA receptor-binding in the frontal cortex of suicide victims, but not in controls. This preliminary study provides little evidence for an important role of NMDA-binding sites in the pathophysiology of depression.

Language: en