Citation

Hrdina PD, Demeter E, Vu TB, Sotonyi P, Palkovits M. Brain Res. 1993; 614(1-2): 37-44.

Affiliation

Department of Pharmacology, University of Ottawa, Ont., Canada.

Copyright

(Copyright © 1993, International Brain Research Organization, Publisher Elsevier Publishing)

DOI

unavailable

PMID

8348328

Abstract

The density (Bmax) of 5-HT2 receptors labelled with 3H.ketanserin was significantly increased in prefrontal cortex (by 67%) and amygdala (by 97%) from suicide/depressives in comparison with controls. There were no differences in Kd of 3H.ketanserin binding between the two groups. The density (Bmax) and affinity (Kd) of 3H.paroxetine sites were not significantly different in the suicide/depressives and controls. The ratio between the density of presynaptic 5-HT uptake sites and postsynaptic 5-HT2 receptors in amygdala was significantly lower in suicide/depressives than in controls. The data confirm and extend some of the previous findings of increases in 5-HT2 receptors in post-mortem brains of suicide victims and depressives who died of natural causes and lend support to the view that an abnormality in brain serotonergic system is associated with depression and suicidal behaviour.

Language: en