SAFETYLIT WEEKLY UPDATE

We compile citations and summaries of about 400 new articles every week.
RSS Feed

HELP: Tutorials | FAQ
CONTACT US: Contact info

Search Results

Journal Article

Citation

Turecki G, Ernst C, Jollant F, Labonté B, Mechawar N. Trends Neurosci. 2012; 35(1): 14-23.

Affiliation

McGill Group for Suicide Studies, Department of Psychiatry, McGill University, Montreal, Canada.

Copyright

(Copyright © 2012, Elsevier Publishing)

DOI

10.1016/j.tins.2011.11.008

PMID

22177979

Abstract

Suicide and related behaviors are complex phenomena associated with different risk factors. Although most individuals who display suicidal behavior do not have a history of early-life adversity, a significant minority does. Recent animal and human data have suggested that early-life adversity leads to epigenetic regulation of genes involved in stress-response systems. Here, we review this evidence and suggest that early-life adversity increases risk of suicide in susceptible individuals by influencing the development of stable emotional, behavioral and cognitive phenotypes that are likely to result from the epigenetic regulation of the hypothalamic-pituitary-adrenal axis and other systems involved in responses to stress.


Language: en

NEW SEARCH


All SafetyLit records are available for automatic download to Zotero & Mendeley
Print