Citation

Walkup JT, Townsend L, Crystal S, Olfson M. Pharmacoepidemiol. Drug Saf. 2012; 21(Suppl 1): 174-182.

Affiliation

Institute for Health, Health Care Policy and Aging Research, Rutgers University, New Brunswick, NJ, USA. walkup@rci.rutgers.edu.

Copyright

(Copyright © 2012, John Wiley and Sons)

DOI

10.1002/pds.2335

PMID

22262604

Abstract

PURPOSE: As part of the Mini-Sentinel pilot program, under contract with the Food and Drug Administration, an effort has been made to evaluate the validity of algorithms useful for identifying health outcomes of interest, including suicide and suicide attempt. METHOD: Literature was reviewed to evaluate how well medical episodes associated with these events could be identified in administrative or claims data sets from the USA or Canada. RESULTS: Six studies were found to include sufficient detail to assess performance characteristics of an algorithm on the basis of International Classification of Diseases, Ninth Revision, E-codes (950-959) for intentional self-injury. Medical records and death registry information were used to validate classification. Sensitivity ranged from 13.8% to 65%, and positive predictive value range from 4.0% to 100%. Study comparisons are difficult to interpret, however, as the studies differed substantially in many important elements, including design, sample, setting, and methods. Although algorithm performance varied widely, two studies located in prepaid medical plans reported that comparisons of database codes to medical charts could achieve good agreement. CONCLUSIONS: Insufficient data exist to support specific recommendations regarding a preferred algorithm, and caution should be exercised in interpreting clinical and pharmacological epidemiological surveillance and research that rely on these codes as measures of suicide-related outcomes. Copyright © 2012 John Wiley & Sons, Ltd.

Language: en