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Citation |
Omrani MD, Bagheri M, Bushehri B, Azizi F, Anoshae MR. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2012; 159B(7): 772-775. |
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Affiliation |
Faculty of Medicine, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. davood_omrani@yahoo.co.uk. |
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Copyright |
(Copyright © 2012, John Wiley and Sons) |
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DOI |
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PMID |
22825972 |
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Abstract |
Many risk factors have been identified for suicide behavior and although a role for cytokines has been suggested in specific psychiatric conditions and suicide behavior, this role is not well-defined. Since some polymorphisms can alter the expression of cytokines, in this study we attempted to assess the role of TGF-β1 codon 10 (T/C) polymorphisms (rs1982073) in suicide behavior. A total of 145 individuals with suicide behavior as well as 200 control participants (without any history of suicide behavior) were included in the study. TGF-β1 codon 10 polymorphism was determined using allele-specific oligonucleotide polymerase chain reaction. Our results demonstrated that the TGF-β1 codon 10 T/T genotype was significantly more prevalent in individuals with suicide behavior (41.7%), in comparison with the controls (27%). The findings of this study demonstrated an association between TGF-β1 (codon 10) T/C polymorphisms and suicide behavior. © 2012 Wiley Periodicals, Inc. Language: en |