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Journal Article

Citation

Villa AF, Tran Hong H, Min Lee H, Chataigner D, Garnier R. Therapie 2012; 67(6): 523-527.

Vernacular Title

Intoxication aiguë par l'indoramine : une revue des 55 cas signalés au Centre antipoison de Paris de 1986 à 2010.

Copyright

(Copyright © 2012, John Libbey Eurotext)

DOI

10.2515/therapie/2012075

PMID

23249578

Abstract

Authors report a retrospective study of all cases of indoramin-only poisoning notified to the Paris poison Centre from 1986 to 2010. Fifty five cases of indoramin self-poisoning were included: 40 adults and 15 children. The mean supposed ingested dose was about 701 mg±464 mg. ECG showed a prolonged QTc interval (equal to or greater than 0.50 s) in 30% of patients. The lowest observed dose for prolonged QTc was 625 mg. This series includes two cases of seizures occurring around two hours after ingestion of 900 and 2 250 mg of indoramin. A review of the literature showed cardiac disorders, with a delayed mechanism of action up until 18 hours after ingestion. Therefore, rapid medical resuscitation and prolonged cardiac monitoring for at least 24 hours after ingestion of 625 mg are recommended.


Language: en

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