Citation

Collins KA, Schiller D. Curr. Top. Behav. Neurosci. 2013; 14: 223-242.

Affiliation

Mt. Sinai School of Medicine, New York, NY, US.

Copyright

(Copyright © 2013, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/7854_2012_236

PMID

23299804

Abstract

The precise neural substrates of major depressive disorder (MDD) remain elusive, and FDA-approved antidepressants fail at least one-third of treatment-seeking patients. It is imperative, therefore, to identify novel research strategies to tackle the factors impeding progress. In this chapter we propose that the knowledge derived from computational investigations of associative learning might offer new insights into the neurobiology of MDD.

Language: en