Citation

Sauber-Schatz EK, Bodnar LM, Weiss HB, Wilson JW, Pearlman MD, Markovic N. Birth Defects Res. A Clin. Mol. Teratol. 2013; 97(10): 641-648.

Affiliation

University of Pittsburgh, Graduate School of Public Health, Department of Epidemiology, Pittsburgh, Pennsylvania; Centers for Disease Control and Prevention, National Center for Injury Research and Control, Division of Unintentional Injury Prevention, Atlanta, Georgia (Currently).

Copyright

(Copyright © 2013, John Wiley and Sons)

DOI

10.1002/bdra.23143

PMID

23893941

Abstract

BACKGROUND: Case reports and series have suggested an association between injury during pregnancy and several nervous system and nervous system-related adverse fetal/neonatal outcomes. This study's purpose is to further determine if there is an association between injury during pregnancy and nervous system birth defects in infancy. METHODS: Through a case-control study, the association between injury during pregnancy and nervous system birth defects was tested using the Texas Birth Defects Registry (1999-2003). Semiautomated probabilistic bias analysis was used to correct for systematic error from misclassification of injury during pregnancy. RESULTS: Of the 59,750 infants eligible for this study, 4144 (6.94%) were diagnosed with a nervous system birth defect and 315 (0.53%) of the infants' mothers were injured during pregnancy. Among these 315 women, 25 (7.94%) delivered an infant with a subsequent nervous system birth defect. The adjusted odds ratio for the association between injury during pregnancy and nervous system birth defects among all study infants was 1.00; 95% confidence interval, 0.63-1.56 and 2.44; 95% confidence interval, 1.08-5.53 among breech presentation infants. Probabilistic bias analysis supported these findings. CONCLUSION: No association between injury during pregnancy and nervous system birth defects was identified. Further exploration into the association among breech presentation infants is warranted. Birth Defects Research (Part A), 2013. © 2013 Wiley Periodicals, Inc.

Language: en