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Journal Article

Citation

Ryterska A, Jahanshahi M, Osman M. Neurosci. Biobehav. Rev. 2013; 37(10 Pt 2): 2836-2846.

Affiliation

Biological and Experimental Psychology, School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.

Copyright

(Copyright © 2013, Elsevier Publishing)

DOI

10.1016/j.neubiorev.2013.10.005

PMID

24157725

Abstract

Parkinson's disease (PD) is associated with motor and cognitive impairment caused by dopamine dysregulation in the basal ganglia. Amongst a host of cognitive deficits, evidence suggests that decision-making is impaired in patients with PD, but the exact scope of this impairment is still unclear. The aim of this review was to establish which experimental manipulations commonly associated with studies involving decision-making tasks were most likely to generate impairments in performance in PD patients. This allowed us to address the question of the exact scope of the decision-making deficits in PD and to hypothesize about the role of the basal ganglia in decision-making processes. We conducted a meta-analysis of available literature, which revealed that the two key predictors of impairment in PD were the feedback structure of the decision-making task and the medication status of patients while performing the tasks. Rather than a global impairment in decision-making ability, these findings suggest that deficiencies in choice-behavior in patients with PD stems from dysfunctions at the outcome evaluation stage of the decision-making process.


Language: en

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