Citation

Van Brussel E, Ghuysen A. Rev. Med. Liege 2014; 69(12): 650-653.

Vernacular Title

Intoxication aiguë volontaire par un carbamate.

Copyright

(Copyright © 2014, Hopital De Baviere)

DOI

unavailable

PMID

25796780

Abstract

Acute poisoning by organophosphate or carbamate is important to recognize since it can cause severe complications such as cardiorespiratory failure, coma, and even death in the absence of early management. Pharmacologically, the mode of action of these substances is based on an inhibition of cholinesterases; the clinical presentation therefore consists of a cholinergic syndrome. The typical clinical picture can be confirmed by the dosage of plasma cholinesterases. On a therapeutic viewpoint, atropine remains the antidote of choice. In high doses, it is the only molecule with a demonstrated effect for the specific treatment of such poisonings. Pralidoxime is clearly recommended in case of poisoning by an organophosphate, but is more discussed when carbamates are involved. The observation of a case of voluntary poisoning by a powerful carbamate, aldicarbe, offers s the opportunity to review the key elements of this type of poisoning. The rather loose inaugural presentation and the initial absence of diagnosis, underline the value of an adequate premature symptomatic care.

Language: fr