Citation

Fox AS, Oler JA, Tromp DP, Fudge JL, Kalin NH. Trends Neurosci. 2015; 38(5): 319-329.

Affiliation

Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA; HealthEmotions Research Institute, University of Wisconsin-Madison, Madison, WI, USA; Lane Neuroimaging Laboratory, University of Wisconsin-Madison, Madison, WI, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI, USA; Center for Investigating Healthy Minds at the Waisman Center, University of Wisconsin-Madison, Madison, WI, USA; Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA.

Copyright

(Copyright © 2015, Elsevier Publishing)

DOI

10.1016/j.tins.2015.03.002

PMID

25851307

Abstract

The central extended amygdala is an evolutionarily conserved set of interconnected brain regions that play an important role in threat processing to promote survival. Two core components of the central extended amygdala, the central nucleus of the amygdala (Ce) and the lateral bed nucleus of the stria terminalis (BST) are highly similar regions that serve complimentary roles by integrating fear- and anxiety-relevant information. Survival depends on the ability of the central extended amygdala to rapidly integrate and respond to threats that vary in their immediacy, proximity, and characteristics. Future studies will benefit from understanding alterations in central extended amygdala function in relation to stress-related psychopathology.

Language: en