Citation

Plant DT, Pariante CM, Sharp D, Pawlby S. Br. J. Psychiatry 2015; 207(3): 213-220.

Affiliation

Dominic T. Plant, PhD, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Carmine M. Pariante, MD, FRCPsych, PhD, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Deborah Sharp, MA, FRCGP, PhD, School of Social and Community Medicine, University of Bristol, UK; Susan Pawlby, MA, PhD, CPsychol, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.

Copyright

(Copyright © 2015, Royal College of Psychiatry)

DOI

10.1192/bjp.bp.114.156620

PMID

26045352

Abstract

BackgroundStudies have shown that maternal depression during pregnancy predicts offspring depression in adolescence. Child maltreatment is also a risk factor for depression.AimsTo investigate (a) whether there is an association between offspring exposure to maternal depression in pregnancy and depression in early adulthood, and (b) whether offspring child maltreatment mediates this association.

METHODProspectively collected data on maternal clinical depression in pregnancy, offspring child maltreatment and offspring adulthood (18-25 years) DSM-IV depression were analysed in 103 mother-offspring dyads of the South London Child Development Study.

RESULTSAdult offspring exposed to maternal depression in pregnancy were 3.4 times more likely to have a DSM-IV depressive disorder, and 2.4 times more likely to have experienced child maltreatment, compared with non-exposed offspring. Path analysis revealed that offspring experience of child maltreatment mediated the association between exposure to maternal depression in pregnancy and depression in adulthood.

CONCLUSIONSMaternal depression in pregnancy is a key vulnerability factor for offspring depression in early adulthood.

Language: en