SAFETYLIT WEEKLY UPDATE

We compile citations and summaries of about 400 new articles every week.
RSS Feed

HELP: Tutorials | FAQ
CONTACT US: Contact info

Search Results

Journal Article

Citation

Conchillo MP, Martinez-Sanchis S, Salvador A, Simon VM. Aggressive Behav. 2002; 28(3): 248-256.

Copyright

(Copyright © 2002, International Society for Research on Aggression, Publisher John Wiley and Sons)

DOI

unavailable

PMID

unavailable

Abstract

The aim of this work was to test the antiaggressive effects of lorazepam and to determine whether these effects were mediated by benzodiazepine receptors. In a first experiment, male mice were injected with lorazepam in a range of low doses (0.05, 0.1, 0.2, and 0.6 mg/kg) or saline solution. In a second experiment, 1 mg/kg of Ro 15-1788, a benzodiazepine receptor antagonist, and a saline solution were injected before the behavioral test. Results showed that 0.6 mg/kg of lorazepam was the only dose that decreased the total duration of threat (P lt .01) and social investigation (P lt .05) and that 1 mg/kg of Ro 15-1788 had no effects. In the third experiment, animals received two injections: 0.6 mg/kg of lorazepam plus 1 mg/kg of Ro 15-1788 0.6 mg/kg of lorazepam plus saline solution, or saline solution plus saline solution. Those treated with lorazepam and saline solution spent less time digging (P lt .001), threatening (P lt .001), and attacking (P lt .05) and more time avoiding the opponent (P lt .01) or being immobile (P lt .001) than the controls. Ro 15-1788 was successful in completely antagonizing the behavior modulated by lorazepam.

NEW SEARCH


All SafetyLit records are available for automatic download to Zotero & Mendeley
Print