Citation

Chou PH, Lin CH, Cheng C, Chang CL, Tsai CJ, Tsai CP, Lan TH, Chan CH. J. Psychiatr. Res. 2015; 68: 186-191.

Affiliation

Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan.

Copyright

(Copyright © 2015, Elsevier Publishing)

DOI

10.1016/j.jpsychires.2015.06.017

PMID

26228418

Abstract

OBJECTIVE: The objective of this study was to assess the risk of depressive disorders in women who underwent hysterectomy in Taiwan.

METHODS: A retrospective study was conducted in a matched cohort of cases using the National Health Insurance Research Database of Taiwan. Database records from 1689 women who underwent hysterectomy between 2001 and 2005 were included in this study. A control group matched for age and physical comorbidity was selected from the same database (n = 6752). For all cases, medical records were tracked until the end of 2009 to identify whether a depressive disorder was diagnosed during the follow-up period. The hazard ratio (HR) for depression during the observation period was analyzed using multivariable Cox proportional-hazards models, adjusted for age, physical comorbidities, and other socioeconomic factors.

RESULTS: The HR for depression was 1.78 times higher for the group that underwent hysterectomy than for the control group (adjusted HR = 1.78; 95% CI = 1.46-2.18, p < 0.001). In addition, HR for major depressive disorder in women who underwent hysterectomy was significantly higher (1.84 times) than for the control group (adjusted HR = 1.84; 95% CI = 1.23-2.74, p < 0.01).

CONCLUSIONS: Our study revealed that, in Taiwan, women who underwent hysterectomy had an increased risk of developing depression. Longitudinal studies to follow-up the psychological outcomes in Taiwanese women who underwent hysterectomy will be necessary to confirm our findings.

Language: en