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Journal Article

Citation

Szmulewicz AG, Smith JM, Valerio MP. Psychiatry Res. 2015; 230(1): 50-55.

Affiliation

Hospital de Emergencias Psiquiátricas Torcuato de Alvear, Av Warnes 2630, Capital Federal, Argentina.

Copyright

(Copyright © 2015, Elsevier Publishing)

DOI

10.1016/j.psychres.2015.07.089

PMID

26260567

Abstract

Patients with schizophrenia have an increased lifetime risk of comorbid obsessive-compulsive symptoms. Up to 30% of these patients experience such symptoms and 12% may be diagnosed with obsessive-compulsive disorder. The presence of these symptoms in schizophrenia seems to be associated with poor outcomes including a greater suicidal risk. A subgroup of patients develops this symptomatology after the initiation with Second Generation Antipsychotics (SGA). Also, there is evidence of a causal relationship for this association, particularly for clozapine. The primary aim of this study was to investigate the association of this comorbidity with suicidality in a population of clozapine-medicated schizophrenic and schizoaffective patients (N=65). The prevalence of obsessive-compulsive symptoms in our sample was 29.2% (N=19) and the prevalence of obsessive-compulsive disorder was 13.8% (N=9). Significant positive correlations between suicidality and total Y-BOCS score and between Y- BOCS score and depressive symptoms were found. Further analysis indicated that a Y-BOCS score greater or equal than 8 was an independent predictor of suicide attempt during clozapine treatment. Routine screening for this adverse event should be warranted for this population.


Language: en

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