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Journal Article

Citation

Gaudiano MC, Borioni A, Antoniella E, Valvo L. J. Forensic Sci. 2016; 61(4): 1126-1130.

Affiliation

Dipartimento del Farmaco, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.

Copyright

(Copyright © 2016, American Society for Testing and Materials, Publisher John Wiley and Sons)

DOI

10.1111/1556-4029.13095

PMID

27364297

Abstract

A nontargeted approach based on liquid chromatography equipped with a quadrupole time-of-flight mass detector (LC-MS Q-TOF) joined to nuclear magnetic resonance (NMR) analysis allowed rapid identification and quantification of the anti-inflammatory drug aceclofenac in illegal Adderall tablets. The largest chromatographic peak had m/z = 354.030 and m/z = 376.012 matching, respectively, the ionic structures (M + H)(+) and (M + Na)(+) of a molecule M. The accurate mass data generated the molecular formula C16 H13 Cl2 NO4. A screening of the pharmaceutical active substances having that molecular formula together with the MS/MS fragmentation pattern suggested aceclofenac. Aceclofenac structure was unambiguously confirmed by (1) H and (13) C NMR experiments. The aceclofenac content was 90 mg/tablet (RSD 2%) as detected by quantitative NMR. Information on the identity and content of illegal drugs is required for legal purposes; it supports in evaluating the effective impact on users safety, and it is useful for control laboratories using a targeted approach in their analytical activities.

© 2016 American Academy of Forensic Sciences.


Language: en

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