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Journal Article

Citation

Bali V, Chatterjee S, Johnson ML, Chen H, Carnahan RM, Aparasu RR. J. Comp. Eff. Res. 2016; 5(5): 461-473.

Copyright

(Copyright © 2016, Future Medicine)

DOI

10.2217/cer-2016-0009

PMID

unavailable

Abstract

AIM: To evaluate comparative safety of paroxetine and other selective serotonin reuptake inhibitors (SSRIs) for the risk of hip fractures. Patients & methods: A propensity score-matched retrospective cohort study was conducted using 2007-2010 Minimum Data Set linked Medicare data. Robust Cox proportional hazards model was used to evaluate the risk of hip fractures in depressed elderly nursing home residents.

RESULTS: Cox analysis did not find any significant difference in the risk of hip fractures for the paroxetine users (hazard ratio: 1.09; 95% CI: 0.91-1.32) when compared with other SSRIs.

RESULTS from the sensitivity analysis supported the main findings.

CONCLUSION: There was no differential risk of hip fractures between paroxetine and other SSRIs. Future studies are needed to evaluate other anticholinergic effects of paroxetine.


Language: en

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