Citation

Lowther S, De Paermentier F, Crompton MR, Katona CL, Horton RW. Brain Res. 1994; 642(1-2): 281-289.

Affiliation

Department of Pharmacology and Clinical Pharmacology, St. George's Hospital Medical School, London, UK.

Copyright

(Copyright © 1994, International Brain Research Organization, Publisher Elsevier Publishing)

DOI

unavailable

PMID

8032889

Abstract

5-HT2 binding sites were quantitated, by saturation binding with [3H]ketanserin, in six brain regions from 73 subjects who died by suicide and 70 sudden death controls. There were no significant differences in the number of 5-HT2 binding sites between suicides and controls in any brain region within the total suicide group or when suicides were divided on the basis of violence of death. Similar results were found when suicides were divided into those with a firm retrospective diagnosis of depression, whether they had been receiving antidepressants or not, and those who were heterogeneous in respect of psychiatric diagnosis and drug treatment. The present findings contrast with previous reports of higher cortical 5-HT2 binding sites in suicides; possible reasons for these differences are discussed.

Language: en