Citation

Boivin DB, James FO, Santo JB, Caliyurt O, Chalk C. Neurology 2003; 60(11): 1841-1843.

Affiliation

Center for Study and Treatment of Circadian Rhythms, Douglas Hospital Research Center, Verdun, Quebec, Canada. boidia@douglas.mcgill.ca

Copyright

(Copyright © 2003, Lippincott Williams and Wilkins)

DOI

unavailable

PMID

12796546

Abstract

The authors report the case of a 39-year-old sighted woman who displayed non-24-hour sleep-wake cycles following a car accident. The phase relationship between endogenous circadian markers such as plasma melatonin and 6-sulfatoxymelatonin rhythms and self-selected sleep times was abnormal. A laboratory investigation indicated that she was sensitive to bright light as a circadian synchronizer. MRI and brain CT scans were normal, but microscopic brain damage in the vicinity of the suprachiasmatic nucleus or its output pathways is plausible.

Language: en