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Journal Article

Citation

Thakur GA, Joober R, Brunet A. J. Trauma. Stress 2009; 22(3): 240-243.

Affiliation

Douglas Mental Health University Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.

Copyright

(Copyright © 2009, International Society for Traumatic Stress Studies, Publisher John Wiley and Sons)

DOI

10.1002/jts.20405

PMID

19444877

Abstract

Association between 5-HTTLPR polymorphism and development of acute and persistence of chronic posttraumatic stress disorder (PTSD) was prospectively investigated. DNA was extracted from 41 motor-vehicle accident victims evaluated for development and persistence of PTSD, 1 and 12 months posttrauma. At Time 1, a nonsignificant trend for higher acute PTSD rate in ll homozygotes (82%) was observed compared to those with ss and sl genotypes (50%). At Time 2, higher chronic PTSD rate was found in ll homozygotes (55%) compared to those with ss and sl genotypes (20%), with an odds ratio of 4.8 (95% CI = 1.09-21.22). Contrary to previous findings, these data are suggestive of a protective role for the s allele of 5-HTTLPR in chronic PTSD.


Language: en

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