Citation

Fraser AD, MacNeil W, Isner AF. J. Forensic Sci. 1991; 36(5): 1596-1602.

Affiliation

Toxicology Laboratory, Victoria General Hospital, Nova Scotia, Canada.

Copyright

(Copyright © 1991, American Society for Testing and Materials, Publisher John Wiley and Sons)

DOI

unavailable

PMID

1955846

Abstract

A fatality following ingestion of the drug baclofen (Lioresal) is described. Baclofen was identified in urine by gas chromatography/mass spectrometry. After derivatization with trinitrobenzene sulfonic acid, baclofen was quantitated in serum and urine by high-performance liquid chromatography. The concentration of baclofen was 17 mg/L in serum and 760 mg/L in urine collected approximately 12 h after the overdose. To our knowledge, this is only the second reported fatality involving a baclofen overdose. The previous case did not include quantitation of baclofen in any biological fluid.

Language: en