Citation

Pardasani D, Palit M, Gupta AK, Shakya P, Sekhar K, Dubey DK. Anal. Chem. 2005; 77(4): 1172-1176.

Affiliation

Vertox Laboratory, Defence Research and Development Establishment, Gwalior, India.

Copyright

(Copyright © 2005, American Chemical Society)

DOI

unavailable

PMID

15859002

Abstract

Off-site analysis of chemical warfare agents (CWAs) and related compounds plays a key role in the verification program of the Chemical Weapons Convention (CWC). The analysis results, aiming toward unambiguous identication of compounds, depend on the type of sample preparation method. Development of milder sample preparation methods, which offer good recoveries and do not alter the structure of analytes, is highly desirable. Organic liquid with high hydrocarbon background is a frequently encountered challenge in off-site analysis and in official proficiency tests conducted by OPCW. Sample cleanup procedures, namely, solvent exchange followed by cooling and liquid-liquid extraction were studied to eliminate the hydrocarbons from organic liquid. Acetonitrile, a polar aprotic solvent, was effectively used to remove the background in both methods, and recoveries of spiked CWAs by the two techniques were between 69 and 99%.

Language: en