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Journal Article

Citation

Cerdá M, Diez-Roux AV, Tchetgen ET, Gordon-Larsen P, Kiefe C. Epidemiology 2010; 21(4): 482-489.

Affiliation

Center for Urban Epidemiologic Studies, New York Academy of Medicine, New York, NY 10029, USA. mcerda@nyam.org

Comment In:

Epidemiology 2010;21(4):490-3.

Copyright

(Copyright © 2010, Lippincott Williams and Wilkins)

DOI

10.1097/EDE.0b013e3181e13539

PMID

20498603

PMCID

PMC3897210

Abstract

BACKGROUND: Previous studies on the relationship of neighborhood disadvantage with alcohol use or misuse have often controlled for individual characteristics on the causal pathway, such as income-thus potentially underestimating the relationship between disadvantage and alcohol consumption.

METHODS: We used data from the Coronary Artery Risk Development in Young Adults study of 5115 adults aged 18-30 years at baseline and interviewed 7 times between 1985 and 2006. We estimated marginal structural models using inverse probability-of-treatment and censoring weights to assess the association between point-in-time/cumulative exposure to neighborhood poverty (proportion of census tract residents living in poverty) and alcohol use/binging, after accounting for time-dependent confounders including income, education, and occupation.

RESULTS: The log-normal model was used to estimate treatment weights while accounting for highly-skewed continuous neighborhood poverty data. In the weighted model, a one-unit increase in neighborhood poverty at the prior examination was associated with a 86% increase in the odds of binging (OR = 1.86 [95% confidence interval = 1.14-3.03]); the estimate from a standard generalized-estimating-equations model controlling for baseline and time-varying covariates was 1.47 (0.96-2.25). The inverse probability-of-treatment and censoring weighted estimate of the relative increase in the number of weekly drinks in the past year associated with cumulative neighborhood poverty was 1.53 (1.02-2.27); the estimate from a standard model was 1.16 (0.83-1.62).

CONCLUSIONS: Cumulative and point-in-time measures of neighborhood poverty are important predictors of alcohol consumption. Estimators that more closely approximate a causal effect of neighborhood poverty on alcohol provided a stronger estimate than estimators from traditional regression models.


Language: en

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