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Journal Article

Citation

Pannu AK, Saroch A, Agrawal J, Sharma N. Trop. Doct. 2018; 48(4): 366-368.

Affiliation

Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Copyright

(Copyright © 2018, SAGE Publishing)

DOI

10.1177/0049475518786834

PMID

30012080

Abstract

2,4-D (2,4-dichlorphenoxyacetic acid) is a chlorphenoxy group pesticide. Its relative safety and broad leaf selectivity makes it a favourite herbicide of many home gardeners and agricultural workers. Severe systemic toxicity requiring hospital admission and intensive care usually occurs following intentional oral ingestion. 2,4-D poisoning is an under-recognised cause of a potentially lethal toxic syndrome, especially in low- and middle-income countries, where such compounds are widely used in farming and readily available in households. It warrants close monitoring and high-quality supportive care along with plasma alkalinisation or extracorporeal removal of the toxin.  We present a short review on 2,4-D poisoning and describe two illustrative cases with significant oral ingestion resulted in early and rapidly developing systemic toxicity. Both patients were admitted to the intensive care unit; one patient was managed with alkaline diuresis and other case required three sessions of haemodialysis.


Language: en

Keywords

2; 4-D; alkaline diuresis; chlorphenoxy; critical care; haemodialysis; herbicide; poisoning

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