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Journal Article

Citation

Hurd D, Arzubi E, Herrera MR, Coombs N, Brant J. CNS Spectr. 2019; 24(1): 183-184.

Affiliation

Nurse Scientist,Collaborative Science and Innovation,Billings Clinic,BillingsMT.

Copyright

(Copyright © 2019, MBL Communications)

DOI

10.1017/S1092852919000142

PMID

30859949

Abstract

OBJECTIVE: This pilot study aims to explore the feasibility and proof of concept of triple chronotherapy (TCT) as a non-pharmacological, adjunctive intervention in the treatment of acute depression and suicidality in the adolescent population.

METHOD: Thirty-one adolescents with moderate to severe depression were included in the study. Each participant underwent a 4-day intervention (TCT) which consisted of one night of sleep deprivation followed by three days of sleep phase advancement and daily bright light therapy. Primary outcomes were feasibility and depression, as measured by Hamilton Depression Scale-17 (HAMD-17) scores. Secondary outcomes included severity of illness, anxiety, self-harm, insomnia, and suicidality.

RESULTS: Twenty-nine (94%) adolescents completed the TCT protocol. Twenty-six (84%) of the 31 enrolled patients experienced a reduction in depressive symptoms of at least 50% from baseline; 24 (77%) achieved remission, defined as a HAMD-17 score less than 8. Secondary outcomes showed significant improvement following the 4-day TCT intervention; improvement was sustained through the 7-10 day and 1-month follow-up periods.

CONCLUSION: This pilot study determined TCT to be a feasible, safe, accelerated, and promising adjunctive treatment for acute depression in the adolescent population. This study has been submitted for publication and is currently under review.


Language: en

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