Citation

Price LM, Poklis A, Johnson DE. J. Forensic Sci. 1991; 36(3): 930-935.

Affiliation

Department of Pathology, Medical College of Virginia, Richmond.

Copyright

(Copyright © 1991, American Society for Testing and Materials, Publisher John Wiley and Sons)

DOI

unavailable

PMID

1856655

Abstract

The authors describe a case of fatal acetaminophen overdose which occurred in a 16-year-old female. Her serum acetaminophen concentration 11.5 h postingestion was 154 mg/L. Antidotal therapy was unsuccessful, and after 9 days she died. Autopsy findings included centrilobular zonal liver necrosis, acute proximal renal tubular necrosis, and diffuse alveolar pulmonary damage. Her heart was transplanted into a young woman with congenital heart disease. The recipient expired 14 days after the transplant as a result of sepsis complicating bowel ischemia. The transplanted heart showed extensive subendocardial myocyte necrosis related to acetaminophen toxicity and not rejection.

Language: en