Citation

Onder AM, Espinoza V, Berho ME, Chandar J, Zilleruelo G, Abitbol C. Pediatr. Nephrol. 2006; 21(11): 1760-1764.

Affiliation

Department of Pediatrics, Division of Pediatric Nephrology, University of Miami Miller School of Medicine, P.O. Box 016960, Miami, FL 33156, USA. alim_md@hotmail.com

Copyright

(Copyright © 2006, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/s00467-006-0196-1

PMID

16897003

Abstract

Phenazopyridine (Pyridium) is a commonly used urinary tract analgesic. It has been associated with yellow skin discoloration, hemolytic anemia, methemoglobinemia, and acute renal failure, especially in patients with preexisting kidney disease. We report a 17-year-old female with vertically transmitted human immunodeficiency virus (HIV) infection, presenting with acute renal failure and methemoglobinemia following a suicidal attempt with a single 1,200 mg ingestion of Pyridium. She had no prior evidence of HIV nephropathy. The patient had a progressive nonoliguric renal failure on the 3rd day following the ingestion. She was treated with N-acetylcysteine, intravenous carnitine, and alkalinization of the urine. Her kidney biopsy revealed acute tubular necrosis with no glomerular changes. After 7 days of conservative management, she was discharged home with normal kidney function. To our knowledge, this is the second smallest amount of Pyridium overdose resulting in acute renal failure with no previous history of kidney disease.

Language: en