Citation

Freedman MD, Sencil SK. Am. J. Ther. 1997; 4(9-10): 327-332.

Affiliation

Sinai Hospital of Baltimore and The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Copyright

(Copyright © 1997, Lippincott Williams and Wilkins)

DOI

unavailable

PMID

10423627

Abstract

Phenytoin metabolism is best described using nonlinear (Michaelis-Menton) kinetics. When calculated pharmacokinetic values, including half life and clearance, do not correspond to measured variables, alternative reasons must be sought. We present an interesting case of phenytoin toxicity and suggest that formation of a bezoar may be one possible answer to prolonged toxicity.

Language: en