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Journal Article

Citation

Jantos R, Schuhmacher M, Veldstra JL, Bosker WM, Klöpping-Ketelaars I, Touliou K, Sardi GM, Brookhuis KA, Ramaekers JG, Mattern R, Skopp G. Arch. Kriminol. 2011; 227(5-6): 188-203.

Vernacular Title

Bestimmung der Blut/Serum-verhaltnisse verschiedener forensisch relevanter

Affiliation

Institut für Rechtsmedizin und Verkehrsmedizin der Universität Heidelberg.

Copyright

(Copyright © 2011, Verlag Schmidt-Romhild)

DOI

unavailable

PMID

21805908

Abstract

For forensic toxicological investigations only whole blood, but no serum is often available. Pharmacokinetic data are helpful for interpreting the results, but most of these studies indicate serum or plasma concentrations. In order to obtain reliable conversion factors which also take intersubject variability into account, the blood/serum ratios (B/S) of oxycodone, morphine, fentanyl, hydromorphone, zopiclone, MDMA, dexamphetamine, alprazolam, risperidone and 9-hydroxyrisperidone were determined by LC-MS/MS using authentic samples. Blood and corresponding serum samples were obtained from driving studies performed with controlled or known dosages of the above drugs. The analytes were analysed in blood and serum and the following mean B/S ratios (relative standard deviations) were determined: oxycodone 1.48 (8.19 %); morphine 1.03 (3.59 %); fentanyl 0.87 (13.9 %); hydromorphone 1.04 (8.11 %); zopiclone 0.89 (16.1 %); MDMA 1.19 (8.04 %); dexamphetamine 0.89 (10.9 %); alprazolam 0.81 (5.84 %); risperidone 0.65 (7.52 %); 9-hydroxyrisperidone 0.73 (12.3 %). These mean values are largely in line with those reported in the literature. The B/S ratios did not appear to depend on partition coefficients, whereas there was strong evidence that B/S ratios decreased with increasing plasma protein binding.


Language: de

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