Citation

Dominicus DA, Todoriki H, Ariizumi M, Akamatsu T. Alcohol Alcohol. 1991; 26(5-6): 597-603.

Affiliation

Department of Preventive Medicine, School of Medicine, University of the Ryukyus, Okinawa, Japan.

Copyright

(Copyright © 1991, Oxford University Press)

DOI

unavailable

PMID

1804139

Abstract

The effect of oral alcohol administration on branched-chain alpha-keto acids was studied in Wistar rats. Rats were divided into alcohol loading groups 1 (ethanol single daily dose: 2.5 g/kg body wt for 14 days) and 2 (ethanol dose: 5 g/kg body wt), and a pair-fed control group (isocaloric glucose and food equal to the amount taken by group 1 the previous day). Branched-chain alpha-keto acids, other alpha-keto acids and amino acids were analysed using high-performance liquid chromatography. Results showed a significant body weight increase in the alcohol loading groups. Concentrations of branched-chain amino acids and keto acids were significantly increased in the alcohol-treated groups. The blood levels of methionine, threonine, alanine and glutamic acid were also increased by alcohol administration. Blood levels of taurine and ornithine, however, showed a significant decrease in the alcohol-treated groups. These results show that alcohol increases the blood levels of branched-chain keto acids and branched-chain amino acids.

Language: en