Citation

Durnova GN, Kaplanskiĭ AS, Alekseev EI, Loginov VI, Nosovskiĭ AM. Aviakosm. Ekolog. Med. 2001; 35(3): 27-31.

Vernacular Title

Stimuliatsiia zazhivleniia perelomov kostei u krys pri defitsite opornykh

Copyright

(Copyright © 2001, Institute of Biomedical Problems)

DOI

unavailable

PMID

11589152

Abstract

Experiment with rats the hind limbs of which were deprived of support loads (tail suspension) for two weeks following operational fracture of fibular bones evidenced inhibited callus formation and lowered strength of bone fragments consolidation. Injection of anabolic steroid retabolite to the traumatized animals together with limited support loading was favorable to the bone callus formation and consolidation of fragments. This measure also distinctly increased the functional activity of adenohypophysial somatotrophs (growth hormone producers) and thyroid C-cells (calcitonine producers). The direct dependence of bone fracture healing on the somatotropic function of the adenohypophysis suggests that the favorable effect of retabolite combined with the support loading is at least partly achieved through the somatorophic function of the adenohypophysis.

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