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Journal Article

Citation

Gambelunghe C, Marsili R, Aroni K, Bacci M, Rossi R. J. Forensic Sci. 2013; 58(1): 270-278.

Affiliation

Department of Clinical and Experimental Medicine, Division of Legal and Sports Medicine, University of Perugia, Padiglione W, via E. dal Pozzo, 06123, Perugia, Italy.

Copyright

(Copyright © 2013, American Society for Testing and Materials, Publisher John Wiley and Sons)

DOI

10.1111/j.1556-4029.2012.02249.x

PMID

22900815

Abstract

Peyote, a cactus containing the hallucinogen mescaline, is used to induce altered states of consciousness in religious ceremonies or for recreational purpose. This study reports a case of an underage boy suspected of mescaline abuse. For this purpose, we analyzed a dark green liquid sample found in the bedroom of the boy whose urine and hair samples were collected shortly after the drink was found. A method by gas chromatography-mass spectrometry tandem mass spectrometry (GC-MS/MS) in positive chemical ionization mode was developed and validated in terms of linearity, specificity, accuracy, and sensitivity for mescaline determination at the low concentrations present in hair. GC-MS analysis of the liquid identified mescaline, while urine was negative; GC-MS/MS segmental hair analysis identified mescaline in the proximal segment (root to 2 cm), while the distal segments were negative. Although peyote was uncommonly encountered, its use was confirmed by segmental hair analysis that can provide long-term information about drugs use.


Language: en

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