Citation

Christianson JP, Fernando AB, Kazama AM, Jovanovic T, Ostroff LE, Sangha S. J. Neurosci. 2012; 32(41): 14118-14124.

Affiliation

Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado 80309-0345, Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom, Department of Developmental Cognitive Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30349, Center for Neural Science, New York University, New York, New York 10003, and Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California 94608.

Copyright

(Copyright © 2012, Society for Neuroscience)

DOI

10.1523/JNEUROSCI.3340-12.2012

PMID

23055481

Abstract

Safety signals are learned cues that predict the nonoccurrence of an aversive event. As such, safety signals are potent inhibitors of fear and stress responses. Investigations of safety signal learning have increased over the last few years due in part to the finding that traumatized persons are unable to use safety cues to inhibit fear, making it a clinically relevant phenotype. The goal of this review is to present recent advances relating to the neural and behavioral mechanisms of safety learning, and expression in rodents, nonhuman primates, and humans.

Language: en