Citation

Feinstein JS, Buzza C, Hurlemann R, Follmer RL, Dahdaleh NS, Coryell WH, Welsh MJ, Tranel D, Wemmie JA. Nat. Neurosci. 2013; 16(3): 270-272.

Affiliation

1] Department of Neurology, University of Iowa, Iowa City, Iowa, USA. [2] Department of Psychology, University of Iowa, Iowa City, Iowa, USA. [3] These authors contributed equally to this work.

Copyright

(Copyright © 2013, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1038/nn.3323

PMID

23377128

Abstract

Decades of research have highlighted the amygdala's influential role in fear. We found that inhalation of 35% CO(2) evoked not only fear, but also panic attacks, in three rare patients with bilateral amygdala damage. These results indicate that the amygdala is not required for fear and panic, and make an important distinction between fear triggered by external threats from the environment versus fear triggered internally by CO(2).

Language: en