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Journal Article

Citation

Kim J, Wessling-Resnick M. J. Nutr. Biochem. 2014; 25(11): 1101-1107.

Affiliation

Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

Copyright

(Copyright © 2014, Elsevier Publishing)

DOI

10.1016/j.jnutbio.2014.07.003

PMID

25154570

Abstract

Iron is required for appropriate behavioral organization. Iron deficiency results in poor brain myelination and impaired monoamine metabolism. Glutamate and γ-aminobutyric acid homeostasis is modified by changes in brain iron status. Such changes produce not only deficits in memory/learning capacity and motor skills, but also emotional and psychological problems. An accumulating body of evidence indicates that both energy metabolism and neurotransmitter homeostasis influence emotional behavior, and both functions are influenced by brain iron status. Like other neurobehavioral aspects, the influence of iron metabolism on mechanisms of emotional behavior is multifactorial: brain region-specific control of behavior, regulation of neurotransmitters and associated proteins, temporal and regional differences in iron requirements, oxidative stress responses to excess iron, sex differences in metabolism, and interactions between iron and other metals. To better understand the role that brain iron plays in emotional behavior and mental health, this review discusses the pathologies associated with anxiety and other emotional disorders with respect to body iron status.


Language: en

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