SAFETYLIT WEEKLY UPDATE

We compile citations and summaries of about 400 new articles every week.
RSS Feed

HELP: Tutorials | FAQ
CONTACT US: Contact info

Search Results

Journal Article

Citation

Leite RT, Nogueira Sde O, do Nascimento JP, de Lima LS, da Nóbrega TB, Virgínio Mda S, Moreno LM, Sampaio BH, Souza FG. Neural Plast. 2015; 2015: e434127.

Affiliation

Department of Clinical Medicine, Federal University of Ceará, 1290 Capitão Francisco Pedro Street, 60430-140 Fortaleza, CE, Brazil.

Copyright

(Copyright © 2015, Hindawi Publishing)

DOI

10.1155/2015/434127

PMID

26097750

PMCID

PMC4444580

Abstract

Introduction. Bipolar disorder (BD) implies risk of suicide. The age at onset (AAO) of BD carries prognostic significance. Substance abuse may precede the onset of BD and cannabis is the most common illicit drug used. The main goal of this study is to review the association of cannabis use as a risk factor for early onset of BD and for suicide attempts.

MATERIALS AND METHODS. PubMed database was searched for articles using key words "bipolar disorder," "suicide attempts," "cannabis," "marijuana," "early age at onset," and "early onset." Results. The following percentages in bipolar patients were found: suicide attempts 3.6-42%; suicide attempts and substance use 5-60%; suicide attempts and cannabis use 15-42%. An early AAO was associated with cannabis misuse. The mean age of the first manic episode in individuals with and without BD and cannabis use disorder (CUD) was 19.5 and 25.1 years, respectively. The first depressive episode was at 18.5 and 24.4 years, respectively. Individuals misusing cannabis showed increased risk of suicide.

DISCUSSION. Cannabis use is associated with increased risk of suicide attempts and with early AAO. However, the effect of cannabis at the AAO and suicide attempts is not clear.


Language: en

NEW SEARCH


All SafetyLit records are available for automatic download to Zotero & Mendeley
Print