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Journal Article

Citation

Schreiner MW, Klimes-Dougan B, Begnel ED, Cullen KR. Neurosci. Biobehav. Rev. 2015; 57: 381-391.

Affiliation

Department of Psychiatry, University of Minnesota Medical School, F268 West Bldg, 2450 Riverside Ave, Minneapolis MN 55454. Electronic address: rega0026@umn.edu.

Copyright

(Copyright © 2015, Elsevier Publishing)

DOI

10.1016/j.neubiorev.2015.09.011

PMID

26424412

Abstract

Non-suicidal self-injury (NSSI) commonly starts in adolescence and is associated with an array of negative outcomes. Neurobiological research investigating NSSI is in its early stages and most studies have examined this behavior within the context of specific diagnoses. However, the Research Domain Criteria (RDoC) initiative encourages researchers to examine brain-behavior relationships across diagnoses. This review on the neurobiology associated with NSSI is organized using the domains proposed by RDoC: Negative Valence, Positive Valence, Cognitive, Social Processes, and Arousal/Regulatory Systems. Evidence of neurobiological anomalies is found in each of these domains. We also propose future research directions, especially in regard to human development. Future NSSI studies should address this behavior independent of diagnosis, examine relevant constructs across multiple units of analysis, and assess how systems change across development and course of illness. These advances will be essential for guiding neurobiologically informed intervention and prevention strategies to target NSSI. In doing so, we may prevent the associated negative outcomes across the lifespan.


Language: en

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