Citation

Podschus J, Dufeu P, Schmidt LG, Sallstrom-Baum S, Rommelspacher H. Addict. Biol. 1997; 2(1): 81-86.

Affiliation

Outpatient Unit for Dependencies, Freie Universität Berlin, GermanyInstitute of Neuropsychopharmacology, Freie Universität Berlin, Germany.

Copyright

(Copyright © 1997, John Wiley and Sons)

DOI

10.1080/13556219772886

PMID

26735443

Abstract

Plasma dopamine, β-carbolines (norharman, harman) and isoquinolines ((R)- and (S)-salsolinol) were examined for their relationship to antisocial tendencies in 138 drinking men with an alcohol dependence syndrome according to ICD-10 criteria. Antisociality was assessed according to the following criteria: delinquency, involvement in fist-fights and homelessness. The personality structure was documented by the Tridimensional Personality Questionnaire of Cloninger. An early age of onset of alcohol dependence and a high degree of 'novelty seeking' were associated with antisocial tendencies. Of the β-carbolines and isoquinolines, harman and (S)-salsolinol were significantly decreased among antisocial alcoholics. Norharman, (R)-salsolinol and dopamine were not associated with antisocial personality. The contribution of endogenous alkaloids to the biological characterization of antisocial tendencies in alcoholics is described.

Language: en