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Citation
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Sorets T, McKenzie E, Cohen J, Cash S, Leung E, Nirola D, Deki S, Tshering L, Wolper E, Mateen F. Neurology 2015; 84(14 Suppl): P2.320. |
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Abstract
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OBJECTIVE: To analyze unintentional injuries among people with epilepsy (PWE) or suspected seizures in a resource-limited setting, including the relationship of injuries to electroencephalography (EEG), seizure frequency, and quality of life.
BACKGROUND: Bhutan is a remote, landlocked, low-income country with a gross national income per capita of 2420USD with a high burden of epilepsy. Unintentional injuries are anecdotally reported to occur among PWE in Bhutan although antiepileptic drugs (AEDs) are freely available. DESIGN/METHODS: Subjects of all ages were recruited in July-August 2014 in an ongoing, prospective, cohort study at the Jigme Dorji Wangchuk National Referral Hospital in Thimphu. Each participant completed an EEG (XLTEK, Natus Medical Inc.) and those 蠅12 years completed a quality of life in epilepsy-31 survey. Standardized interviews in English or Dzhongka were administered to the participant or proxy as appropriate.
RESULTS: A quarter of participants (26/106, 46[percnt] female, mean age 24 years) reported unintentional injuries (14 head injuries, 9 burns, 5 fractures/joint dislocations, 1 motor vehicle accident (>1 injury/person possible)). Participants with unintentional injuries were more likely to have an abnormal EEG (18/52, 34.6[percnt] versus 8/54, 14.8[percnt], p=0.025) and epileptiform abnormalities (15/37, 40.5[percnt] versus 11/69 15.9[percnt], p>0.05 for both) but less likely to be treated with an AED (26.9[percnt] versus 50.0[percnt], p=0.04). There were no significant differences in the mean number of seizures self-reported in the prior month (4 versus 8) or mean QOLIE-31 score (48.3 versus 48.9) (p>0.05 for both). After adjustment for age, sex, AED treatment, and seizure number, a normal EEG remained strongly associated with lower odds of unintentional injuries (OR 0.19, 95[percnt]CI 0.07-0.57, p=0.03) CONCLUSION:In resource-limited settings, EEG provide clinically relevant information to PWE and suspected seizures, leading to better provider identification of those at risk of serious unintentional injuries than clinical interview alone. Study Supported by: Grand Challenges Canada, Thrasher Foundation.
Disclosure: Dr. Sorets has nothing to disclose. Dr. McKenzie has nothing to disclose. Dr. Cohen has nothing to disclose. Dr. Cash has nothing to disclose. Dr. Leung has nothing to disclose. Dr. Nirola has nothing to disclose. Dr. Deki has nothing to disclose. Dr. Tshering has nothing to disclose. Dr. Wolper has nothing to disclose. Dr. Mateen has nothing to disclose.
Language: en |