Citation

Andrade P, Nissinen J, Pitkänen A. J. Neurotrauma 2016; 34(7): 1482-1487.

Affiliation

University of Eastern Finland, A.I.Virtanen Institute, Kuopio, Finland ; asla.pitkanen@uef.fi.

Copyright

(Copyright © 2016, Mary Ann Liebert Publishers)

DOI

10.1089/neu.2016.4675

PMID

27707084

Abstract

Sleep disturbances commonly occur after traumatic brain injury and may predispose patients to epileptic seizures. We hypothesized that unprovoked seizure occurrence after traumatic brain injury depends on the sleep-wake cycle, and that the electrographic characteristics of a given sleep stage provide biomarkers for post-traumatic epilepsy. We show in a rat lateral fluid-percussion model that 92% of spontaneous generalized seizures occur during the transition from stage III to rapid-eye-movement sleep. Moreover, a reduction in spindle duration and dominant frequency during the transition stage present as specific and sensitive non-invasive biomarkers for experimentally induced post-traumatic epilepsy with generalized electrographic seizures.

Language: en