Citation

Kulicki P, Głogowski T. Wiad. Lek. 2016; 69(5): 729-731.

Affiliation

Katedra i Klinika Nefrologii, Dializoterapii i Chorób Wewnętrznych WUM, Warszawa, Polska.

Copyright

(Copyright © 2016, Polskie Towarzystwo Laekarskie)

DOI

unavailable

PMID

28033596

Abstract

Accidental or intentional poisonings with ethylene glycol or methanol constitute a serious toxicological problem in many countries. Both alcohols are quickly metabolized by alcohol dehydrogenase to toxic metabolites responsible for high anion gap severe metabolic acidosis and profound neurological, cardiopulmonary, renal disturbances and death. In the early period, the competing inhibition the alcohol dehydrogenase with ethanol or fomepizol may successfully prevent the formation of the toxic metabolites. Once severe acidosis develops an emergency hemodialysis is required.

Language: pl