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Journal Article

Citation

Hunter LE, Branch CA, Lipton ML. Neurobiol. Dis. 2019; 123: 122-126.

Affiliation

The Gruss Magnetic Resonance Imaging Center, USA; Departments of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA; Departments of Psychiatry & Behavioral Sciences, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA; The Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.

Copyright

(Copyright © 2019, Elsevier Publishing)

DOI

10.1016/j.nbd.2018.06.016

PMID

29936233

Abstract

It is now recognized that repetitive head impacts (RHI) in sport have the potential for long-term neurological impairments. In order to identify targets for intervention and/or pharmacological treatment it is necessary to characterize the neurobiological mechanisms associated with RHI. This review aims to summarize animal and human studies that specifically address Blood Brain Barrier (BBB) dysfunction, abnormal neuro-metabolic and neuro-inflammatory processes as well as Tau aggregation associated with RHI in collision sports. Additionally, we examine the influence of physical activity and genetics on outcomes of RHI, discuss methodological considerations, and provide suggestions for future directions of this burgeoning area of research.

Copyright © 2018. Published by Elsevier Inc.


Language: en

Keywords

Collision sports; Mild traumatic brain injury; Repetitive head injuries

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