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Journal Article

Citation

Farmer A, Redman K, Harris T, Mahmood A, Sadler S, McGuffin P. Br. J. Psychiatry 2001; 178: 549-552.

Affiliation

Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Denmark Hill, London, UK.

Copyright

(Copyright © 2001, Royal College of Psychiatry)

DOI

unavailable

PMID

11388972

Abstract

BACKGROUND: The relationship between adversity and genetic risk factors in depression could be mediated by familial 'hazard prone' traits, as reflected in high levels of sensation-seeking. AIMS: To examine whether high sensation-seeking scores are associated with more adverse life events resulting in depression. METHOD: In a sib-pair design, 108 probands with depression and their siblings and 105 healthy control subjects and their siblings were compared for psychopathology, life events and scores on the Sensation-Seeking Questionnaire (SSQ). RESULTS: The SSQ scores were correlated negatively with depression, were familial and were correlated positively with less severe events, but not the severe events typically associated with depressive onsets. CONCLUSIONS: The SSQ measures a familial personality trait and depression is associated with lower scores. Although high sensation-seeking is associated with a higher rate of life events, these carry little threat.


Language: en

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