@article{ref1,
title="Effects of escapable and inescapable stressors on behavior and interleukin-2 in the brain",
journal="Neuroreport",
year="2008",
author="Lee, Ya Ting and Wang, Wen-Fu and Cheng, Chun-Wen and Wu, Shey-Lin and Pawlak, Cornelius R. and Ho, Ying-Jui",
volume="19",
number="12",
pages="1243-1247",
abstract="This study aimed to clarify the effects of inescapable and escapable stressors on behavior and interleukin-2 (IL-2) levels in the brain. Inescapable trials, consisting of pairings of conditioned and unconditioned stimuli, were used to induce fear-conditioned stress, whereas trials of escapable pairings of conditioned and unconditioned stimuli in an active avoidance test were used as acute and conditioned stressors. IL-2 levels in the brain were analyzed by enzyme-linked immunoadsorbent assays. Inescapable and escapable stressors had different effects on behavior in the modified active avoidance test and on IL-2 levels in brain areas that are known to be involved in emotional processes. These data provide insight into the pathophysiological role of IL-2 in stress-related disorders.<p /><p>Language: en</p>",
language="en",
issn="0959-4965",
doi="10.1097/WNR.0b013e32830b5d86",
url="http://dx.doi.org/10.1097/WNR.0b013e32830b5d86"
}