@article{ref1,
title="Inferior frontal white matter volume and suicidality in schizophrenia",
journal="Psychiatry research",
year="2008",
author="Rüsch, Nicolas and Spoletini, Ilaria and Wilke, Marko and Martinotti, G. and Bria, P. and Trequattrini, Alberto and Bonaviri, G. and Caltagirone, Carlo and Spalletta, Gianfranco",
volume="164",
number="3",
pages="206-214",
abstract="The neurobiology of suicidality in schizophrenia is largely unknown. We therefore assessed gray and white matter volumes associated with past suicidality and current self-aggression in schizophrenia. Fifty-five outpatients with schizophrenia (n=55) and healthy controls (n=55), matched for age, gender and handedness, were recruited. Ten patients had a life-time history of one or more suicide attempts. Current self-aggression was assessed using the Modified Overt Aggression Scale. High resolution structural magnetic resonance images were analyzed by voxel-based morphometry. We found significantly larger inferior frontal white matter volumes bilaterally in patients with a previous suicide attempt as compared with those patients without a history of suicidality. No other significant white or gray matter volume differences were observed. White matter volume in these regions did not differ between healthy controls and those patients without a previous suicide attempt. Furthermore, among patients, the level of current self-aggression showed a significant positive correlation with white matter volume in the same regions. Inferior frontal white matter alterations in fronto-temporo-limbic circuits may be associated with suicidality and self-aggression in schizophrenia.<p /> <p>Language: en</p>",
language="en",
issn="0165-1781",
doi="10.1016/j.pscychresns.2007.12.011",
url="http://dx.doi.org/10.1016/j.pscychresns.2007.12.011"
}